Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

Three-dimensional (3D), submillimeter-scale constructs of neural cells, known as cortical
spheroids, are of rapidly growing importance in biological research because these systems …

The biofabrication of three-dimensional (3D) tissues that recapitulate organ-specific
architecture and function would benefit from temporal and spatial control of cell-cell …

Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …

Neural progenitor cell (NPC) culture within three-dimensional (3D) hydrogels is an attractive
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …

The mammalian brain is composed of an outer layer of gray matter, consisting of cell bodies,
dendrites, and unmyelinated axons, and an inner core of white matter, consisting primarily of …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …

Emerging micro-scale medical devices are showing promise, whether in delivering drugs or
extracting diagnostic biomarkers from skin. In progressing these devices through animal …