The thioredoxin antioxidant system
J Lu, A Holmgren - Free radical biology and medicine, 2014 - Elsevier
The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
Oxidative stress, protein damage and repair in bacteria
B Ezraty, A Gennaris, F Barras, JF Collet - Nature Reviews Microbiology, 2017 - nature.com
Oxidative damage can have a devastating effect on the structure and activity of proteins, and
may even lead to cell death. The sulfur-containing amino acids cysteine and methionine are …
may even lead to cell death. The sulfur-containing amino acids cysteine and methionine are …
The cell biology of phagocytosis
Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …
components of the innate immune response. In addition, phagocytosis is also required for …
Mycobacterial survival strategies in the phagosome: defence against host stresses
S Ehrt, D Schnap**er - Cellular microbiology, 2009 - Wiley Online Library
Infections with Mycobacterium tuberculosis remain a major cause of disease and death in
humans. Among the factors that contribute to M. tuberculosis's success as a pathogen is its …
humans. Among the factors that contribute to M. tuberculosis's success as a pathogen is its …
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase …
Macrophages in granulomas are both antimycobacterial effector and host cell for
Mycobacterium tuberculosis, yet basic aspects of macrophage diversity and function within …
Mycobacterium tuberculosis, yet basic aspects of macrophage diversity and function within …
The Response of Mycobacterium Tuberculosis to Reactive Oxygen and Nitrogen Species
MI Voskuil, IL Bartek, K Visconti… - Frontiers in …, 2011 - frontiersin.org
The bacteriostatic and bactericidal effects and the transcriptional response of
Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were …
Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were …
Mycobacterial dormancy systems and host responses in tuberculosis
Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …
Adaptation to adversity: the intermingling of stress tolerance and pathogenesis in enterococci
Enterococcus is a diverse and rugged genus colonizing the gastrointestinal tract of humans
and numerous hosts across the animal kingdom. Enterococci are also a leading cause of …
and numerous hosts across the animal kingdom. Enterococci are also a leading cause of …
Redox homeostasis in mycobacteria: the key to tuberculosis control?
Mycobacterium tuberculosis (Mtb) is a metabolically flexible pathogen that has the
extraordinary ability to sense and adapt to the continuously changing host environment …
extraordinary ability to sense and adapt to the continuously changing host environment …
Reactive species and pathogen antioxidant networks during phagocytosis
L Piacenza, M Trujillo, R Radi - Journal of Experimental Medicine, 2019 - rupress.org
The generation of phagosomal cytotoxic reactive species (ie, free radicals and oxidants) by
activated macrophages and neutrophils is a crucial process for the control of intracellular …
activated macrophages and neutrophils is a crucial process for the control of intracellular …