The gradual deterioration of physiological systems with ageing makes it difficult to maintain
skeletal muscle mass (sarcopenia), at least partly due to the presence of 'anabolic …

Bedrest as an experimental paradigm or as an in-patient stay for medical reasons has
negative consequences for cardiovascular health. The effects of severe inactivity parallel …

Background Phenotypic frailty syndrome identifies older adults at greater risk for adverse
health outcomes. Despite the critical role of mitochondria in maintaining cellular function …

Background Skeletal muscle energetics decline with age, and physical activity (PA) has
been shown to offset these declines in older adults. Yet, many studies reporting these effects …

Performance fatigability is typically experienced as insufficient energy to complete daily
physical tasks, particularly with advancing age, often progressing toward dependency. Thus …

Objective Our objective was to investigate the overall and sex‐specific relationships
between the presence and severity of knee osteoarthritis (KOA) and muscle composition …

Oxidative stress is considered a contributor to declining muscle function and mobility during
aging; however, the underlying molecular mechanisms remain poorly described. We …

Gene expression in skeletal muscle of older individuals may reflect compensatory
adaptations in response to oxidative damage that preserve tissue integrity and maintain …

Background Walking slows with aging often leading to mobility disability. Mitochondrial
energetics has been found to be associated with gait speed over short distances …

The connection between the respiratory capacity of skeletal muscle mitochondria and
athletic performance is widely acknowledged in contemporary research. Building on a solid …