Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Supercritical fluids possess the unique properties of behaving like liquids and gases, above
their critical point. Supercritical fluid technology has recently emerged as a green and novel …

Since the Handbook of Pharmaceutical Granulation Technology, first and second editions,
were published, there have been rapid developments in the science of granulation, particle …

Supercritical fluid (SCF) processes have attracted great attention for fabricating micro and
nanoparticles in the pharmaceutical applications. Herein we utilized, for the first time, Gas …

In the pharmaceutical industry, an even greater number of products are in the form of
particulate solids. Their formation, formulation and the control of their user properties are still …

A method of rapid expansion of supercritical solutions with solid cosolvent (RESS-SC) was
applied, for the first time, to precipitate nanoparticles of Letrozole (LTZ). Solubility of LTZ, as …

In the present investigation, the solubility of two drugs ie, phenytoin and raloxifene, was
obtained in supercritical CO 2 at various temperatures and pressures. The obtained results …

In this first of two articles, we discuss some issues surrounding the dissolution rate
enhancement of poorly-soluble active ingredients micronized into nano-particles using …

Fexofenadine hydrochloride is an antihistamine drug which is used in the treatment of
allergy symptoms, like urticaria and hay fever. In this research, the solubility of fexofenadine …

In situ ATR (attenuated total reflectance)–IR spectroscopy has been used to study poly
(vinylpyrrolidone)(PVP) films subjected to a solution of ibuprofen in supercritical CO2. The …