Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Background Multiple sclerosis is an inflammatory demyelinating disease of the central
nervous system and is the most common cause of neurologic disability in young adults …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Diffusion tensor imaging has been used extensively as a research tool to understand the
structural changes associated with white matter pathology. Using water diffusion as the …

Dedifferentiation of myelinating Schwann cells is a key feature of nerve injury and
demyelinating neuropathies. We review recent evidence that this dedifferentiation depends …

Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of
the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but …

Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many
people to have an autoimmune aetiology. In recent years, new data emerging from …

Sialic acids (Sias) are terminal components of many glycoproteins and glycolipids especially
of higher animals. In this exposed position they contribute significantly to the structural …

Myelination increases neuronal conduction velocity through its insulating properties and an
unidentified extrinsic effect that increases axonal caliber. Although it is well established that …