Extending the landscape of omics technologies by pathomics

RD Bülow, DL Hölscher, IG Costa, P Boor - npj Systems Biology and …, 2023 - nature.com
Tissue analysis is vital for investigating disease mechanisms and guiding diagnostics, eg, in
cancer, communicable or noncommunicable diseases. During the last decades …

[HTML][HTML] Fenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease

X Mou, SM Leeman, Y Roye, C Miller… - International Journal of …, 2024 - mdpi.com
In the human body, the vascular system plays an indispensable role in maintaining
homeostasis by supplying oxygen and nutrients to cells and organs and facilitating the …

Deep learning applications for kidney histology analysis

P Pilva, R Bülow, P Boor - Current Opinion in Nephrology and …, 2024 - journals.lww.com
Deep learning offers great opportunities to improve quantitative and qualitative kidney
histology analysis for research and clinical nephropathology diagnostics. Although exciting …

[HTML][HTML] The Protective Role of Intermedin in Contrast-Induced Acute Kidney Injury: Enhancing Peritubular Capillary Endothelial Cell Adhesion and Integrity Through …

T Gao, R Gu, H Wang, L Li, B Zhang, J Hu… - International Journal of …, 2024 - mdpi.com
Contrast-induced acute kidney injury (CIAKI) is a common complication with limited
treatments. Intermedin (IMD), a peptide belonging to the calcitonin gene-related peptide …

tRigon: an R package and Shiny App for integrative (path-) omics data analysis

DL Hölscher, M Goedertier, BM Klinkhammer… - BMC …, 2024 - Springer
Background Pathomics facilitates automated, reproducible and precise histopathology
analysis and morphological phenoty**. Similar to molecular omics, pathomics datasets …

Clinical relevance of computational pathology analysis of interplay between kidney microvasculature and interstitial microenvironment

Y Chen, B Wang, D Demeke, F Fan… - Clinical Journal of the …, 2024 - journals.lww.com
Background: Interstitial fibrosis and tubular atrophy (IFTA), and density and shape of
peritubular capillaries (PTCs), are independently prognostic of disease progression. This …

The Quest for the Application of Artificial Intelligence to Whole Slide Imaging: Unique Prospective from New Advanced Tools

G Faa, M Castagnola, L Didaci, F Coghe, M Scartozzi… - Algorithms, 2024 - mdpi.com
The introduction of machine learning in digital pathology has deeply impacted the field,
especially with the advent of whole slide image (WSI) analysis. In this review, we tried to …

Clinical relevance of computationally derived tubular features: spatial relationships and the development of tubulointerstitial scarring in MCD/FSGS

F Fan, Q Liu, J Zee, T Ozeki, D Demeke, Y Yang… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Background Visual scoring of tubular damage has limitations in capturing the full spectrum
of structural changes and prognostic potential. We investigate if computationally quantified …

Long‐term, automated stool monitoring using a novel smart toilet: A feasibility study

J Zhou, Y Luo, JW Darcy, KJ Lafata… - …, 2025 - Wiley Online Library
Background Patients' report of bowel movement consistency is unreliable. We demonstrate
the feasibility of long‐term automated stool image data collection using a novel Smart Toilet …

FUSION: A web-based application for in-depth exploration of multi-omics data with brightfield histology

S Border, RM Ferreira, N Lucarelli, D Manthey… - …, 2024 - pmc.ncbi.nlm.nih.gov
Spatial–OMICS technologies facilitate the interrogation of molecular profiles in the context of
the underlying histopathology and tissue microenvironment. Paired analysis of …