Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

An overview of microRNAs

SM Hammond - Advanced drug delivery reviews, 2015 - Elsevier
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

[HTML][HTML] A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating
physiological processes and cancer pathogenesis have been a revolutionary discovery over …

New insights into long noncoding RNAs and their roles in glioma

Z Peng, C Liu, M Wu - Molecular cancer, 2018 - Springer
Glioma is one of the most prevalent types of primary intracranial carcinoma with varying
malignancy grades I–IV and histological subtypes, including astrocytomas, glioblastoma …

microRNA therapeutics in cancer—an emerging concept

MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …

LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer

A Bhan, SS Mandal - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2015 - Elsevier
Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in
various cellular and physiological processes such as in gene regulation, chromatin …

Chemotherapy resistance in epithelial ovarian cancer: Mechanisms and emerging treatments

C Marchetti, F De Felice, A Romito, V Iacobelli… - Seminars in Cancer …, 2021 - Elsevier
Ovarian cancer (OC) remains a fatal malignancy because most patients experience
recurrent disease, which is resistant to chemotherapy. The outcomes for patients with …

Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment

B van Zyl, D Tang, NA Bowden - Endocrine-related cancer, 2018 - erc.bioscientifica.com
Ovarian cancer has poor survival rates due to a combination of diagnosis at advanced
disease stages and disease recurrence as a result of platinum chemotherapy resistance …

Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy

KKW To, Z Huang, H Zhang, CR Ashby Jr, L Fu - Drug Resistance Updates, 2024 - Elsevier
Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …