The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …

Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

Chimeric antigen receptor (CAR) technology is having a huge impact in the blood
malignancy field and is becoming a well-established therapy for many types of leukaemia. In …

BACKGROUND We evaluated the safety and viral rebound, after analytical treatment
interruption (ATI), of vedolizumab and ART in recent HIV-1 infection. We used this model to …

Background An HIV-1 vaccine is long overdue. Although vaccine research focuses on the
induction of broadly neutralising antibodies, challenging infections such as HIV-1 could …

Targeting the CNS remains a potential problem for the currently investigated HIV curing
strategies. In vivo evidence on CNS effectiveness is limited for most of the investigated …

Viruses have the ability to modulate the cellular machinery of their host to ensure their
survival. While humans encounter numerous viruses daily, only a select few can lead to …

HIV affects more than 38 million people worldwide. Although HIV can be effectively treated
by lifelong combination antiretroviral therapy, only a handful of patients have been cured …

Several studies have shown promise in many preclinical models of disease, including
simian immunodeficiency virus (SIV)/SHIV infection in nonhuman primates and HIV infection …

Identifying a vaccine capable of generating durable T cell responses that target mutationally
vulnerable epitopes and that can rapidly intercept infecting or rebounding virus remains a …