Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …

Preterm birth is the leading cause of neonatal morbidity and mortality. Although the
underlying causes of pregnancy-associated complication are numerous, it is well …

This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-
associated cell death, and necrosis. The authors discuss the clinical implications of each of …

Neurogenesis—the formation of new neurons in the adult brain—is considered to be one of
the mechanisms by which the brain maintains its lifelong plasticity in response to extrinsic …

TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host
material released during injury. For unknown reasons, renal TLR2 mRNA is mainly …

It was originally thought that a cell's major histocompatibility complex (MHC) class I
molecules presented peptides derived exclusively from proteins synthesized by the cell …

Abstract McBride, WH, Chiang, CS., Olson, JL, Wang, CC., Hong, JH., Pajonk, F., Dougherty,
GJ, Iwamoto, KS, Pervan, M. and Liao, YP. A Sense of Danger from Radiation. Radiat. Res …

Mounting scientific evidence over decades has established that atherosclerosis is a chronic
inflammatory disorder. Among the potentially critical sources of vascular inflammation during …

Atherosclerosis is increasingly recognized as a chronic inflammatory disease. Although a
variety of inflammatory markers (ie, C-reactive protein) have been associated with …

The critical role of Toll‐like receptors (TLRs) as mediators of pathogen recognition by the
innate immune system is now firmly established. Such recognition results in the initiation of …