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Biology and therapeutic targeting of vascular endothelial growth factor A
L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …
process in which several families of regulators have been implicated. Among these, vascular …
[HTML][HTML] Long COVID or post-acute sequelae of COVID-19 (PASC): an overview of biological factors that may contribute to persistent symptoms
AD Proal, MB VanElzakker - Frontiers in microbiology, 2021 - frontiersin.org
The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused
a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients …
a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients …
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …
are known as tumour-associated macrophages (TAMs). These specialized immune cells …
Reactive oxygen species in macrophages: sources and targets
M Canton, R Sánchez-Rodríguez, I Spera… - Frontiers in …, 2021 - frontiersin.org
Reactive oxygen species (ROS) are fundamental for macrophages to eliminate invasive
microorganisms. However, as observed in nonphagocytic cells, ROS play essential roles in …
microorganisms. However, as observed in nonphagocytic cells, ROS play essential roles in …
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Q Wu, L You, E Nepovimova, Z Heger, W Wu… - Journal of hematology & …, 2022 - Springer
Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms
J Loo, DA Spittle, M Newnham - Thorax, 2021 - thorax.bmj.com
Thrombotic events that frequently occur in COVID-19 are predominantly venous
thromboemboli (VTE) and are associated with increasing disease severity and worse clinical …
thromboemboli (VTE) and are associated with increasing disease severity and worse clinical …
Hypoxia and the tumor microenvironment
Y Li, L Zhao, XF Li - Technology in cancer research & …, 2021 - journals.sagepub.com
Hypoxia is an important feature of the tumor microenvironment, and is closely associated
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …
The role of macrophages in cancer development and therapy
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …
development of tumors, modulation of neoangiogenesis, immune suppression, and …
Anemia in chronic kidney disease: from pathophysiology and current treatments, to future agents
Anemia is a common complication in chronic kidney disease (CKD), and is associated with a
reduced quality of life, and an increased morbidity and mortality. The mechanisms involved …
reduced quality of life, and an increased morbidity and mortality. The mechanisms involved …