The cell biology of ferroptosis
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
C Scarpellini, G Klejborowska, C Lanthier… - Trends in …, 2023 - cell.com
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …
Ferroptosis: mechanisms, biology and role in disease
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …
Exploiting ferroptosis vulnerabilities in cancer
Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This
process has been increasingly contemplated as a new target for cancer therapy because of …
process has been increasingly contemplated as a new target for cancer therapy because of …
[HTML][HTML] Ferroptosis in health and disease
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …
Ferroptosis, radiotherapy, and combination therapeutic strategies
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …
Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis
B Zhang, X Chen, F Ru, Y Gan, B Li, W **a, G Dai… - Cell Death & …, 2021 - nature.com
Renal fibrosis is a common pathological process that occurs with diverse etiologies in
chronic kidney disease. However, its regulatory mechanisms have not yet been fully …
chronic kidney disease. However, its regulatory mechanisms have not yet been fully …
The metabolic underpinnings of ferroptosis
Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …
Nutritional and metabolic control of ferroptosis
Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …