To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the develo** neuron. Regulation of polymer …

Spatially controlled polymerization of actin is at the origin of cell motility and is responsible
for the formation of cellular protrusions like lamellipodia. The pathogens Listeria …

Motile and morphogenetic cellular processes are driven by site-directed assembly of actin
filaments. Formins, proteins characterized by formin homology domains FH1 and FH2, are …

The β-thymosins are a family of highly conserved polar 5 kDa peptides originally thought to
be thymic hormones. About 10 years ago, thymosin β4 as well as other members of this …

It is now well established that the small GTPases of the Rho family—Rac, Cdc42 and Rho—
regulate growth cone morphology. Less clear is their role in guiding the growth cone. Do …

We develop a mathematical model that describes key details of actin dynamics in protrusion
associated with cell motility. The model is based on the dendritic-nucleation hypothesis for …

The actin cytoskeleton is a vital component of several key cellular and developmental
processes in eukaryotes. Many proteins that interact with filamentous and/or monomeric …

Cell motility is crucial for tissue formation and for development of organisms. Later on cell
migration remains essential throughout the lifetime of the organism for wound healing and …

The actin cytoskeleton plays a central role in many cell biological processes. The structure
and dynamics of the actin cytoskeleton are regulated by numerous actin-binding proteins …