The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Research on the neurobiology of the kynurenine pathway has suffered years of relative
obscurity because tryptophan degradation, and its involvement in both physiology and major …

Glucose transporters (GLUTs) at the blood-brain barrier maintain the continuous high
glucose and energy demands of the brain. They also act as therapeutic targets and provide …

Neurotransmission between neurons, which can occur over the span of a few milliseconds,
relies on the controlled release of small molecule neurotransmitters, many of which are …

J. Neurochem.(2011) 117, 333–345. Abstract We have obtained, for the first time, a
quantitative protein expression profile of membrane transporters and receptors in human …

This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

Tryptophan is an indispensable amino acid that should to be supplied by dietary protein.
Apart from its incorporation into body proteins, tryptophan is the precursor for serotonin, an …

The clinicopathologic entity of cerebral congophilic or amyloid angiopathy (CAA) has been
recognized since die early part of this century, though it has attained the'limelight'over the …

To evaluate the potential contribution of circulating kynurenines to brain kynurenine pools,
the rates of cerebral uptake and mechanisms of blood–brain barrier transport were …

Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …