Objective To investigate the impact of patient and public involvement (PPI) on rates of
enrolment and retention in clinical trials and explore how this varies with the context and …

This review presents the current state of the art regarding multiparametric magnetic
resonance (MR) imaging of prostate cancer. Technical requirements and clinical indications …

Abstract Background The 4Kscore combines measurement of four kallikreins in blood with
clinical information as a measure of the probability of significant (Gleason≥ 7) prostate …

Background In 2008, we reported that radical prostatectomy, as compared with watchful
waiting, reduces the rate of death from prostate cancer. After an additional 3 years of follow …

Testing for prostate-specific antigen (PSA) has profoundly affected the diagnosis and
treatment of prostate cancer. PSA testing has enabled physicians to detect prostate tumours …

ContextThe appropriate therapy for men with clinically localized prostate cancer is uncertain.
A recent study suggested an increasing prostate cancer mortality rate for men who are alive …

Purpose: Several new extended prostate biopsy schemes (greater than 6 cores) have been
proposed. We compared the cancer detection rates and complications of different extended …

Objective To examine the evidence on the benefits and harms of screening for prostate
cancer. Design Systematic review and meta-analysis of randomised controlled trials. Data …

Background The benefit of radical prostatectomy in patients with early prostate cancer has
been assessed in only one randomized trial. In 2005, we reported that radical prostatectomy …

Background Prostate cancer is a major public health problem with considerable
uncertainties about the effectiveness of population screening and treatment options. We …