[HTML][HTML] Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions
Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …
[HTML][HTML] Biomechanics of the human intervertebral disc: a review of testing techniques and results
Many experimental testing techniques have been adopted in order to provide an
understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this …
understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this …
Molecular mechanisms of biological aging in intervertebral discs
NV Vo, RA Hartman, PR Patil… - Journal of …, 2016 - Wiley Online Library
Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
Diversity of intervertebral disc cells: phenotype and function
The intervertebral disc (IVD) is a moderately moving joint that is located between the bony
vertebrae and provides flexibility and load transmission throughout the spinal column. The …
vertebrae and provides flexibility and load transmission throughout the spinal column. The …
Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its …
BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
Fundamental biomechanics of the spine—what we have learned in the past 25 years and future directions
TR Oxland - Journal of biomechanics, 2016 - Elsevier
Since the publication of the 2nd edition of White and Panjabi׳ s textbook, Clinical
Biomechanics of the Spine in 1990, there has been considerable research on the …
Biomechanics of the Spine in 1990, there has been considerable research on the …
Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level
Purpose Mechanical loading represents an integral part of intervertebral disc (IVD)
homeostasis. This review aims to summarise recent knowledge on the effects of mechanical …
homeostasis. This review aims to summarise recent knowledge on the effects of mechanical …
Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies
OM Torre, V Mroz, MK Bartelstein… - Annals of the New …, 2019 - Wiley Online Library
Despite considerable efforts to develop cellular, molecular, and structural repair strategies
and restore intervertebral disk function after injury, the basic biology underlying …
and restore intervertebral disk function after injury, the basic biology underlying …
Spine biomechanical testing methodologies: the controversy of consensus vs scientific evidence
Biomechanical testing methodologies for the spine have developed over the past 50 years.
During that time, there have been several paradigm shifts with respect to techniques. These …
During that time, there have been several paradigm shifts with respect to techniques. These …
[HTML][HTML] Genipin-crosslinked fibrin hydrogels as a potential adhesive to augment intervertebral disc annulus repair
Abstract Treatment of damaged intervertebral discs is a significant clinical problem and,
despite advances in the repair and replacement of the nucleus pulposus, there are few …
despite advances in the repair and replacement of the nucleus pulposus, there are few …