Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

MJ Doenhoff, D Cioli, J Utzinger - Current opinion in infectious …, 2008 - journals.lww.com
Use of PZQ will increase in the foreseeable future, whether given alone or coadministered
with other anthelminthics in integrated control programmes. PZQ resistance remains a threat …

Natural products as a source for treating neglected parasitic diseases

D Ndjonka, LN Rapado, AM Silber, E Liebau… - International Journal of …, 2013 - mdpi.com
Infectious diseases caused by parasites are a major threat for the entire mankind, especially
in the tropics. More than 1 billion people world-wide are directly exposed to tropical …

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

SD Melman, ML Steinauer… - PLoS neglected …, 2009 - journals.plos.org
Background The near exclusive use of praziquantel (PZQ) for treatment of human
schistosomiasis has raised concerns about the possible emergence of drug-resistant …

Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis

G Riveau, D Deplanque, F Remoue… - PLoS neglected …, 2012 - journals.plos.org
Background Treatment of urinary schistosomiasis by chemotherapy remains challenging
due to rapid re-infection and possibly to limited susceptibility to praziquantel treatment …

A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?

S Summers, T Bhattacharyya, F Allan… - Frontiers in Tropical …, 2022 - frontiersin.org
Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …

New approaches for understanding mechanisms of drug resistance in schistosomes

RM Greenberg - Parasitology, 2013 - cambridge.org
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical
disease that affects hundreds of millions worldwide. Treatment and control of …

H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies

RP Xavier, AC Mengarda, MP Silva, DB Roquini… - Parasites & …, 2020 - Springer
Background Schistosomiasis is a socioeconomically devastating parasitic infection afflicting
hundreds of millions of people and animals worldwide. It is the most important helminth …

Licochalcone A-Loaded Solid Lipid Nanoparticles Improve Antischistosomal Activity In Vitro and In Vivo

LM Silva, DG Marconato, MP Nascimento da Silva… - …, 2021 - Taylor & Francis
Aim: To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid
nanoparticles (L-SLNs) and evaluate the L-SLNs in vitro and in vivo against Schistosoma …

[HTML][HTML] Novel therapeutic and prevention approaches for schistosomiasis

RAF El Ridi, HAM Tallima - Journal of Advanced Research, 2013 - Elsevier
Schistosomiasis is a debilitating disease affecting approximately 600 million people in 74
develo** countries, with 800 million, mostly children at risk. To circumvent the threat of …

A Recycled-Material-Based Electrochemical Eco-sensor for Sensitive Detection of Antischistosomal Drug Residues in Bovine-Derived Food Samples

KAM Attia, AEF Abbas, A El-Olemy, NA Abdelshafi… - BioChip Journal, 2024 - Springer
Veterinary drug residues in food have emerged as an urgent threat to consumer safety.
Herein, we present the first square wave voltammetric method for the trace-level detection of …