With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …

Linear accelerator-based free-electron lasers (FELs) are the leading source of fully coherent
X-rays with ultra-high peak powers and ultra-short pulse lengths. Current X-ray FEL facilities …

This review highlights recent efforts on applying electron microscopy (EM) to soft (including
biological) nanomaterials. We will show how developments of both the hardware and …

With the advent of structural biology in the drug discovery process, medicinal chemists
gained the opportunity to use detailed structural information in order to progress screening …

The SwissFEL X-ray Free Electron Laser (XFEL) facility started construction at the Paul
Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in …

A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …

G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …

Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Knowledge gained through x-ray crystallography fostered structural determination of
materials and greatly facilitated the development of modern science and technology in the …