The cytoprotective protein C pathway
Protein C is best known for its mild deficiency associated with venous thrombosis risk and
severe deficiency associated with neonatal purpura fulminans. Activated protein C (APC) …
severe deficiency associated with neonatal purpura fulminans. Activated protein C (APC) …
Reprint of Crosstalk between inflammation and thrombosis
CT Esmon - Maturitas, 2008 - Elsevier
Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Multiple mechanisms
are at play including up regulation of tissue factor leading to the initiation of clotting …
are at play including up regulation of tissue factor leading to the initiation of clotting …
Resistance to activated protein C as a basis for venous thrombosis
Background In three families with various forms of venous thrombosis, we observed an
apparently inherited poor response to the anticoagulant activated protein C (APC). The …
apparently inherited poor response to the anticoagulant activated protein C (APC). The …
Dysfunction of endothelial protein C activation in severe meningococcal sepsis
Background Impairment of the protein C anticoagulation pathway is critical to the thrombosis
associated with sepsis and to the development of purpura fulminans in meningococcemia …
associated with sepsis and to the development of purpura fulminans in meningococcemia …
A protein catalytic framework with an N-terminal nucleophile is capable of self-activation
THE crystal structures of three amidohydrolases have been determined recently1–3:
glutamine PRPP amidotransferase (GAT), penicillin acylase, and the proteasome. These …
glutamine PRPP amidotransferase (GAT), penicillin acylase, and the proteasome. These …
Activated protein C drives the hyperfibrinolysis of acute traumatic coagulopathy
Background Major trauma is a leading cause of morbidity and mortality worldwide with
hemorrhage accounting for 40% of deaths. Acute Traumatic Coagulopathy (ATC) …
hemorrhage accounting for 40% of deaths. Acute Traumatic Coagulopathy (ATC) …
Activated protein C
Protein C is a vitamin K‐dependent plasma protein zymogen whose genetic mild or severe
deficiencies are linked with risk for venous thrombosis or neonatal purpura fulminans …
deficiencies are linked with risk for venous thrombosis or neonatal purpura fulminans …
Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V.
Recently, our laboratory described a defect in anticoagulant response to activated protein C
(APC). This response, APC resistance, was shown to be inherited and associated with …
(APC). This response, APC resistance, was shown to be inherited and associated with …
Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway
C Adrie, M Monchi, I Laurent, S Um, SB Yan… - Journal of the American …, 2005 - jacc.org
Objectives: We investigated coagulation abnormalities in out-of-hospital cardiac arrest
(OHCA) patients, with special attention to the protein C anticoagulant pathway. Background …
(OHCA) patients, with special attention to the protein C anticoagulant pathway. Background …
Endothelial cell protein C receptor plays an important role in protein C activation in vivo
FB Taylor Jr, GT Peer, MS Lockhart… - Blood, The Journal …, 2001 - ashpublications.org
Endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-
thrombomodulin complex about 5-fold in vitro. Augmentation is EPCR concentration …
thrombomodulin complex about 5-fold in vitro. Augmentation is EPCR concentration …