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Bladder cancer: current challenges and future directions
Bladder cancer (BCa) is the most common malignancy of the urinary tract and one of the
most prevalent cancers worldwide. While the clinical approach to BCa has remained largely …
most prevalent cancers worldwide. While the clinical approach to BCa has remained largely …
Treatment of muscle‐invasive and advanced bladder cancer in 2020
Bladder cancer accounts for nearly 170,000 deaths worldwide annually. For over 4 decades,
the systemic management of muscle‐invasive and advanced bladder cancer has primarily …
the systemic management of muscle‐invasive and advanced bladder cancer has primarily …
Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial
Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-
altering. We initiated a phase 2 study in which patients with MIBC received four cycles of …
altering. We initiated a phase 2 study in which patients with MIBC received four cycles of …
Pembrolizumab as neoadjuvant therapy before radical cystectomy in patients with muscle-invasive urothelial bladder carcinoma (PURE-01): an open-label, single …
Purpose To determine the activity of pembrolizumab as neoadjuvant immunotherapy before
radical cystectomy (RC) for muscle-invasive bladder carcinoma (MIBC) for which standard …
radical cystectomy (RC) for muscle-invasive bladder carcinoma (MIBC) for which standard …
Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline
SS Chang, BH Bochner, R Chou, R Dreicer… - The Journal of …, 2017 - auajournals.org
Purpose: This multidisciplinary, evidence-based guideline for clinically non-metastatic
muscle-invasive bladder cancer focuses on the evaluation, treatment and surveillance of …
muscle-invasive bladder cancer focuses on the evaluation, treatment and surveillance of …
Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy
Background An early report on the molecular subty** of muscle-invasive bladder cancer
(MIBC) by gene expression suggested that response to neoadjuvant chemotherapy (NAC) …
(MIBC) by gene expression suggested that response to neoadjuvant chemotherapy (NAC) …
Alterations in DNA damage response and repair genes as potential marker of clinical benefit from PD-1/PD-L1 blockade in advanced urothelial cancers
Purpose Alterations in DNA damage response and repair (DDR) genes are associated with
increased mutation load and improved clinical outcomes in platinum-treated metastatic …
increased mutation load and improved clinical outcomes in platinum-treated metastatic …
Safety and efficacy of durvalumab (MEDI4736), an anti–programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder …
Purpose To investigate the safety and efficacy of durvalumab, a human monoclonal antibody
that binds programmed cell death ligand-1 (PD-L1), and the role of PD-L1 expression on …
that binds programmed cell death ligand-1 (PD-L1), and the role of PD-L1 expression on …
Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors
Alterations in DNA repair pathways are common in tumors and can result in characteristic
mutational signatures; however, a specific mutational signature associated with somatic …
mutational signatures; however, a specific mutational signature associated with somatic …
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
A Taber, E Christensen, P Lamy, I Nordentoft… - Nature …, 2020 - nature.com
Overtreatment with cisplatin-based chemotherapy is a major issue in the management of
muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for …
muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for …