The functions and biochemical mechanisms involved in cell signalling by phosphoinositide
breakdown are now well defined[l-3]. drolysis of polyphosphoinositides (PI) yieI motes rhe …

The nicotinic acetylcholine receptor (AChR) is the archetype molecule in the superfamily of
ligand-gated ion channels (LGIC). Members of this superfamily mediate fast intercellular …

Lysophosphatidic acid (LPA) is a water-soluble phospholipid with hormone-like and growth-
factor-like activities. LPA activates a putative G-protein-coupled receptor in responsive cells …

Although ketamine's primary site of action appears to be the phencyclidine receptor on the N-
methyl-D-aspartate (NMDA) receptor complex, additional activity on opiate and quisqualate …

Lysophosphatidic acid (LPA) is a mitogenic phospholipid produced by certain activated cells
and present in serum. LPA stimulates phospholipase C and inhibits adenylate cyclase in its …

Abbreviations 151 I. Historical background of biologically active phospholipids 152 II. PAF
homologues and analogues! 53 A. r) istribntion in the animal kingdom 153 B. Formation of …

Lysophosphatidic acids (LPAs) are known to be normal constituents of mammalian serum,
and they mimic some biological effects of the serum. We previously reported that …

Lysophosphatidic acid (LPA) induces mitogenic responses in cultured fibroblasts through a
pertussis toxin-sensitive signaling pathway. In contrast, we have shown that LPA inhibits the …

Biochi~& et Biophysica A~ta Page 1 ELSEVIER Biochimica et Biophysica Acta 1198 (1994)
185-196 BB, Biochi~& et Biophysica A~ta Growth factor-like effects of lysophosphatidic acid …

Although local anesthetics are considered primarily Na+ channel blockers, previous studies
suggest a common intracellular site of action on different G protein-coupled receptors. In the …