Gram-negative bacteria possess an outer membrane layer which constrains uptake and
secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed …

Pathogenic microorganisms have to face hostile environments while colonizing and
infecting their hosts. Unfortunately, they can cope with it and have evolved a number of …

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the
United States. The precise role of bacterial infection in the course and pathogenesis of …

Bacterial pathogens must execute a prodigious array of complex functions in order to
survive, multiply, and disseminate within mammalian hosts. Virulence determinants are …

We have identified and characterized a secreted protein, designated Pic, which is encoded
on the chromosomes of enteroaggregative Escherichia coli (EAEC) 042 and Shigella …

The autotransporters, a family of secreted proteins from Gram-negative bacteria, possess an
overall unifying structure comprising three functional domains: the amino-terminal leader …

Autotransporters are a superfamily of proteins that use the type V secretion pathway for their
delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to …

Autotransporters are a large and diverse superfamily of proteins produced by pathogenic
gram-negative bacteria that are composed of an N-terminal passenger domain, which …

The temperature-sensitive hemagglutinin Tsh is a member of the autotransporter group of
proteins and was first identified in avian-pathogenic Escherichia coli (APEC) strain χ7122 …

Autotransporters are virulence‐related proteins of Gram‐negative bacteria that are secreted
via an outer‐membrane‐based C‐terminal extension, the translocator domain. This domain …