Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

The epicardium, the outer epithelial layer that covers the myocardium, derives from a
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …

Heart organoids have the potential to generate primary heart-like anatomical structures and
hold great promise as in vitro models for cardiac disease. However, their properties have not …

Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that
recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a …

Cardiovascular disease is a significant cause of death in humans. Various models are
necessary for the study of cardiovascular diseases, but once cellular and animal models …

The phospholamban (PLN) p. Arg14del mutation causes dilated cardiomyopathy, with the
molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were …

Cardiovascular diseases (CVDs) are globally known to be important causes of mortality and
disabilities. Common treatment strategies for CVDs, such as pharmacological therapeutics …

A simplified and cost-effective culture system for maintaining the pluripotency of human
induced pluripotent stem cells (hiPSCs) is crucial for stem cell applications. Although …