Intravitreal injection of therapeutic agents

GA Peyman, EM Lad, DM Moshfeghi - Retina, 2009 - journals.lww.com
Background: Intravitreal injection (IVI) with administration of various pharmacological agents
is a mainstay of treatment in ophthalmology for endopthalmitis, viral retinitis, age-related …

Local delivery of corticosteroids in clinical ophthalmology: A review

AT Fung, T Tran, LL Lim… - Clinical & …, 2020 - Wiley Online Library
Locally administered steroids have a long history in ophthalmology for the treatment of
inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids …

Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice

V Lambert, J Lecomte, S Hansen, S Blacher… - Nature protocols, 2013 - nature.com
The mouse model of laser-induced choroidal neovascularization (CNV) has been used
extensively in studies of the exudative form of age-related macular degeneration (AMD) …

Intravitreal bevacizumab treatment of choroidal neovascularization secondary to age-related macular degeneration

RF Spaide, K Laud, HF Fine, JR JAMES M KLANCNIK… - Retina, 2006 - journals.lww.com
Purpose: To describe the short-term anatomical and visual acuity responses after intravitreal
injection of bevacizumab (Avastin, Genentech) in patients with choroidal neovascularization …

Twelve-month safety of intravitreal injections of bevacizumab (Avastin®): results of the Pan-American Collaborative Retina Study Group (PACORES)

L Wu, MA Martínez-Castellanos… - Graefe's archive for …, 2008 - Springer
Background Vascular endothelial growth factor (VEGF) plays an important role in many
diseases of the posterior pole that are characterized by macular edema and/or intraocular …

Transplantation of the RPE in AMD

S Binder, BV Stanzel, I Krebs, C Glittenberg - Progress in retinal and eye …, 2007 - Elsevier
The retinal pigment epithelium (RPE) maintains retinal function as the metabolic gatekeeper
between photoreceptors (PRs) and the choriocapillaries. The RPE and Bruch's membrane …

[HTML][HTML] Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration

AC Amrite, HF Edelhauser, SR Singh… - Molecular vision, 2008 - ncbi.nlm.nih.gov
Purpose Our previous studies indicated that while 20 nm particles are rapidly cleared from
the periocular space of the rat following posterior subconjunctival injection, 200 nm particles …

Age-related macular degeneration: diagnosis and management

HL Cook, PJ Patel, A Tufail - British medical bulletin, 2008 - academic.oup.com
Background Age-related macular degeneration (AMD) is a leading cause of blind
registration in Western Europe and the third leading cause of blindness worldwide. Methods …

Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration

H Hayashi, K Yamashiro, A Tsujikawa, M Ota… - American journal of …, 2009 - Elsevier
PURPOSE: To evaluate the correlation between visual outcome and foveal photoreceptor
integrity after successful treatment of eyes with neovascular age-related macular …

Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: aqueous dexamethasone eye drops

T Loftsson, D Hreinsdóttir… - Journal of pharmacy and …, 2007 - Wiley Online Library
Delivery of steroids to the retina is currently undertaken with invasive injections into the
vitreous cavity. This paper describes a non‐invasive method to deliver steroids in …