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Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Nanotechnology-based strategies against SARS-CoV-2 variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more
than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 …
than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 …
Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2
Continued emergence of SARS-CoV-2 variants of concern that are capable of esca**
vaccine-induced immunity highlights the urgency of develo** new COVID-19 therapeutics …
vaccine-induced immunity highlights the urgency of develo** new COVID-19 therapeutics …
Folding@ home: Achievements from over 20 years of citizen science herald the exascale era
Simulations of biomolecules have enormous potential to inform our understanding of biology
but require extremely demanding calculations. For over 20 years, the Folding@ home …
but require extremely demanding calculations. For over 20 years, the Folding@ home …
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo
N Ikemura, S Taminishi, T Inaba, T Arimori… - Science translational …, 2022 - science.org
The Omicron (B. 1.1. 529) SARS-CoV-2 variant contains an unusually high number of
mutations in the spike protein, raising concerns of escape from vaccines, convalescent …
mutations in the spike protein, raising concerns of escape from vaccines, convalescent …
Engineering ACE2 decoy receptors to combat viral escapability
Decoy receptor proteins that trick viruses to bind to them should be resistant to viral escape
because viruses that require entry receptors cannot help but bind decoy receptors …
because viruses that require entry receptors cannot help but bind decoy receptors …
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
L Zhang, KK Narayanan, L Cooper… - EMBO molecular …, 2022 - embopress.org
Monoclonal antibodies targeting the SARS‐CoV‐2 spike (S) neutralize infection and are
efficacious for the treatment of COVID‐19. However, SARS‐CoV‐2 variants, notably …
efficacious for the treatment of COVID‐19. However, SARS‐CoV‐2 variants, notably …
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
Soluble angiotensin-converting enzyme 2 (ACE2) constitutes an attractive antiviral capable
of targeting a wide range of coronaviruses using ACE2 as their receptor. Using structure …
of targeting a wide range of coronaviruses using ACE2 as their receptor. Using structure …
Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo
As severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) evolves to escape
natural antibodies, it also loses sensitivity to therapeutic antibody drugs. By contrast …
natural antibodies, it also loses sensitivity to therapeutic antibody drugs. By contrast …