Y chromosome microdeletions and alterations of spermatogenesis
Three different spermatogenesis loci have been mapped on the Y chromosome and named
“azoospermia factors”(AZFa, b, and c). Deletions in these regions remove one or more of the …
“azoospermia factors”(AZFa, b, and c). Deletions in these regions remove one or more of the …
The biology and evolution of mammalian Y chromosomes
Mammals have the oldest sex chromosome system known: the mammalian X and Y
chromosomes evolved from ordinary autosomes beginning at least 180 million years ago …
chromosomes evolved from ordinary autosomes beginning at least 180 million years ago …
Microdeletions in the Y chromosome of infertile men
JL Pryor, M Kent-First, A Muallem… - … England Journal of …, 1997 - Mass Medical Soc
Background Some infertile men with azoospermia or severe oligospermia have small
deletions in regions of the Y chromosome. However, the frequency of such microdeletions …
deletions in regions of the Y chromosome. However, the frequency of such microdeletions …
Defining regions of the Y‐chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y‐chromosome microdeletion detection
M Kent‐First, A Muallem, J Shultz… - Molecular …, 1999 - Wiley Online Library
Cytogenetic and molecular deletion analyses of azoospermic and oligozoospermic males
have suggested the existence of AZoospermia Factor (s)(AZF) residing in deletion intervals …
have suggested the existence of AZoospermia Factor (s)(AZF) residing in deletion intervals …
Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility
Three distinct regions, designated AZFa, b and c from proximal to distal Yq, are required for
normal spermatogenesis in humans. Deletions involving AZFa (deletion interval 5C/D) seem …
normal spermatogenesis in humans. Deletions involving AZFa (deletion interval 5C/D) seem …
Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI
BACKGROUND: Severe spermatogenic compromise may be the result of a Y-chromosomal
deletion of the AZFc region. Prior studies are limited to relatively small numbers of AZFc …
deletion of the AZFc region. Prior studies are limited to relatively small numbers of AZFc …
[PDF][PDF] Laboratory guidelines for molecular diagnosis of Y‐chromosomal microdeletions
The heterogeneity of the protocols employed and of the results published, together with the
increasing diffusion of this diagnostic procedure, suggested the necessity of a quality control …
increasing diffusion of this diagnostic procedure, suggested the necessity of a quality control …
High frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome
Idiopathic Sertoli cell-only syndrome (SCOS) Is characterized by azoospermia, small testes,
absence of germ cells In the testes, elevated Mick stimulating hormone and normal …
absence of germ cells In the testes, elevated Mick stimulating hormone and normal …
[PDF][PDF] Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update.
PH Vogt - Molecular human reproduction, 1998 - Citeseer
Human chromosome deletions in Yq11 seem to occur frequently as de novo mutation events
in men with idiopathic azoospermia or severe oligozoospermia. However, the molecular …
in men with idiopathic azoospermia or severe oligozoospermia. However, the molecular …
The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers
Microdeletions linked to deletion intervals 5 and 6 of the Y chromosome have been
associated with male factor infertility. Members from at least two gene families lie in the …
associated with male factor infertility. Members from at least two gene families lie in the …