Common pitfalls in drug target Mendelian randomization and how to avoid them
Abstract Background Drug target Mendelian randomization describes the use of genetic
variants as instrumental variables for studying the effects of pharmacological agents. The …
variants as instrumental variables for studying the effects of pharmacological agents. The …
[HTML][HTML] Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management
A Kaltsas, F Dimitriadis, A Zachariou, N Sofikitis… - Cells, 2025 - mdpi.com
Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as
pivotal regulators of male reproductive physiology, exerting significant influence on testicular …
pivotal regulators of male reproductive physiology, exerting significant influence on testicular …
Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization …
J Chen, Y Liu, P Zhan, T Gao, J Zuo, X Li… - Sexual …, 2024 - academic.oup.com
Background The causal relationship between certain immune cells and erectile dysfunction
(ED) is still uncertain. Aim The study sought to investigate the causal effect of 731 types of …
(ED) is still uncertain. Aim The study sought to investigate the causal effect of 731 types of …
A comprehensive assessment of the association between common drugs and psychiatric disorders using Mendelian randomization and real-world pharmacovigilance …
Z Chen, X Wang, Z Teng, J Huang, J Mo, C Qu, Y Wu… - …, 2024 - thelancet.com
Background Medications prescribed for chronic diseases can lead to short-term
neuropsychiatric symptoms, but their long-term effects on brain structures and psychiatric …
neuropsychiatric symptoms, but their long-term effects on brain structures and psychiatric …
Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry
A Schuermans, A Verstraete, V Lammi, T Nakanishi… - medRxiv, 2024 - medrxiv.org
SARS-CoV-2 infection can result in long COVID, characterized by post-acute symptoms from
multiple organs. Current hypotheses on mechanisms underlying long COVID include …
multiple organs. Current hypotheses on mechanisms underlying long COVID include …
Glucagon-like peptide-1 receptor agonists and the risk of erectile dysfunction: a drug target Mendelian randomization study
H An, K **e, H Gan - Frontiers in Endocrinology, 2024 - frontiersin.org
Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been widely used
for type 2 diabetes (T2D) and weight management. However, the causal relationship of GLP …
for type 2 diabetes (T2D) and weight management. However, the causal relationship of GLP …
The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study
J Peng, J An, Y Chen, J Zhou, B **ang - Sexual Medicine, 2024 - academic.oup.com
Background While previous studies have explored the associations and causalities among
platelet count (PC), mean platelet volume (MPV), and erectile dysfunction (ED), further …
platelet count (PC), mean platelet volume (MPV), and erectile dysfunction (ED), further …
[HTML][HTML] 人吸入性损伤与循环炎症蛋白之间因果关系的双样本孟德尔随机化分析
代站站， 朱沁， 佟希睿， 马兵， 夏照帆… - 中华烧伤与创面修复 …, 2024 - zhsszz.xml-journal.net
目的探究人吸入性损伤与循环炎症蛋白之间的因果关系. 方法该研究为基于双样本孟德尔随机化
(MR) 分析的研究. 以吸入性损伤为暴露因素, 循环炎症蛋白为结局, 从全基因组关联分析数据库 …
(MR) 分析的研究. 以吸入性损伤为暴露因素, 循环炎症蛋白为结局, 从全基因组关联分析数据库 …
Natural experiments with sildenafil and stiffness
B Woolf - bmj, 2023 - bmj.com
In August 2020, I found myself being taken by ambulance to the intensive care unit (ICU) at
the Royal Brompton Hospital. For the preceding year I had been getting progressively more …
the Royal Brompton Hospital. For the preceding year I had been getting progressively more …
Mendelian randomization study of sodium–glucose cotransporter 2 inhibitors in cardiac and renal diseases
L Chen, Y Zuo, M He, L Duo… - Journal of International …, 2024 - journals.sagepub.com
Objective Sodium–glucose cotransporter 2 inhibitors (SGLT2i) target the reabsorption of
sodium and glucose in the kidney proximal tubules to reduce blood sugar levels. However …
sodium and glucose in the kidney proximal tubules to reduce blood sugar levels. However …