A community-based transcriptomics classification and nomenclature of neocortical cell types

R Yuste, M Hawrylycz, N Aalling, A Aguilar-Valles… - Nature …, 2020 - nature.com
To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …

[HTML][HTML] Establishing neuronal diversity in the spinal cord: a time and a place

A Sagner, J Briscoe - Development, 2019 - journals.biologists.com
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

[HTML][HTML] Molecular architecture of the mouse nervous system

A Zeisel, H Hochgerner, P Lönnerberg, A Johnsson… - Cell, 2018 - cell.com
The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

DH Brann, T Tsukahara, C Weinreb, M Lipovsek… - Science …, 2020 - science.org
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

A harmonized atlas of mouse spinal cord cell types and their spatial organization

DE Russ, RBP Cross, L Li, SC Koch… - Nature …, 2021 - nature.com
Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

[HTML][HTML] A cellular taxonomy of the adult human spinal cord

A Yadav, KJE Matson, L Li, I Hua, J Petrescu, K Kang… - Neuron, 2023 - cell.com
The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

[HTML][HTML] An atlas of vagal sensory neurons and their molecular specialization

J Kupari, M Häring, E Agirre, G Castelo-Branco… - Cell reports, 2019 - cell.com
Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

Genetic map** of cell type specificity for complex traits

K Watanabe, M Umićević Mirkov, CA de Leeuw… - Nature …, 2019 - nature.com
Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific
transcriptome profiles. Such profiles can be aligned with genome-wide association studies …

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

S Maniatis, T Äijö, S Vickovic, C Braine, K Kang… - Science, 2019 - science.org
Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of
skeletal muscle as a consequence of motor neuron degeneration. Interactions between …

Parallel ascending spinal pathways for affective touch and pain

S Choi, J Hachisuka, MA Brett, AR Magee, Y Omori… - Nature, 2020 - nature.com
The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature
and touch information from the spinal cord to the brain,,–. Projection neurons of the …