Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …

Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia
induced by infarction leads to profound changes in endothelial cell functions and can induce …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …