Abstract Vacuolation, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is
a multisystem disease due to a genetic mutation in the ubiquitin-activating enzyme (UBA1) …

Mutations in UBA1, which are disease-defining for VEXAS (vacuoles, E1 enzyme, X-linked,
autoinflammatory, somatic) syndrome, have been reported in patients diagnosed with …

Somatic mutations of the X-linked UBA1 gene in myeloid progenitors constitute the
molecular underpinnings of VEXAS, typically occurring in men during the sixth decade of …

Simple Summary Several recent studies have demonstrated encouraging results in treating
patients with myelodysplastic syndromes/neoplasms (MDSs). This review focuses on the …

The VEXAS syndrome, a genetically defined autoimmune disease, associated with various
hematological neoplasms has been attracting growing attention since its initial description in …

In the current review, we discuss the novelties for VEXAS, including pathogenic pathways,
epidemiological data, diagnostic criteria and algorithms, treatment options and …

VEXAS syndrome is a new disease entity with symptoms that can mimic hematological,
rheumatic and dermatological diseases. It is important to take a multidisciplinary approach to …

VEXAS syndrome is a haemato‐inflammatory disease caused by somatic UBA1 mutations
and characterized by cytoplasmic vacuoles in myeloid and erythroid precursor cells …

VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is an
increasingly recognized disorder that occurs due to somatic mutations of a ubiquitin …

VEXAS syndrome is a complex hemato-inflammatory disorder, driven by somatic mutations
in the UBA1 gene within hematopoietic precursor cells. It is characterized by systemic …