Two-photon microscopy is used to image neuronal activity, but has severe limitations for
studying deeper cortical layers. Here, we developed a custom three-photon microscope …

Background and Objectives Technological advances in medicine have brought about many
novel skin imaging devices. This review aims to evaluate the scientific evidence supporting …

Confocal Raman microscopy has been used to measure depth‐dependent profiles of
porcine skin ex vivo in the high wavenumber region after application of molecular optical …

This short review describes recent progress in using optical clearing (OC) technique in skin
studies. Optical clear-ing is an efficient tool for enhancing the probing depth and data quality …

Second-harmonic generation microscopy is a valuable label-free modality for imaging non-
centrosymmetric structures and has important biomedical applications from live-cell imaging …

Thin tissue slice based histology has been used as a gold standard for disease diagnosis
since over a hundred years ago. However, histopathological evaluation on two-dimensional …

Confocal Raman microscopy (CRM) is employed to study the skin physiology, drug
permeation and skin disease monitoring. In order to increase the depth of investigations, the …

Importance Improvements in skin appearance resulting from treatment with fractionated
picosecond‐lasers have been noted, but optimizing the treatment efficacy depends on a …

We introduce a compact, fast large area multiphoton exoscope (FLAME) system with
enhanced molecular contrast for macroscopic imaging of human skin with microscopic …

Melasma is a skin disorder characterized by hyperpigmented patches due to increased
melanin production and deposition. In this pilot study, we evaluate the potential of …