Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with
over 370 structures in total bound to different ligands and the receptors in various …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins in
the human genome and are important therapeutic targets. During the last decade, the …

Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Dysregulation of peptide-activated pathways causes a range of diseases, fostering the
discovery and clinical development of peptide drugs. Many endogenous peptides activate G …

G protein-coupled receptors (GPCRs) are targets for∼ 35% of approved drugs but only∼
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …

Many drug targets are embedded within the phospholipid bilayer of cellular membranes,
including G protein-coupled receptors, ion channels, transporters and membrane-bound …

Kinases are a prime target of drug development efforts with> 60 drug approvals in the past
two decades. Due to the research into this protein family, a wealth of data has been …

G protein-coupled receptors (GPCRs) are expressed in a variety of cell types and tissues,
and activation of GPCRs is involved in enormous metabolic pathways, including nutrient …