The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …

Aim: An outstanding challenge in epigenome studies is the estimation of cell-type
proportions in complex epithelial tissues. Materials & methods: Here, we construct and …

Introduction Environmental factors are poorly understood in the etiology of Alzheimer's
disease (AD) and related dementias. The importance of environmental factors in gene …

Background: It has been estimated that a substantial portion of chronic and
noncommunicable diseases can be caused or exacerbated by exposure to environmental …

Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …

Epidemiological evidence of the effects of PM2. 5 elements on lung function and DNA
methylation is limited. We conducted a longitudinal panel study of 76 healthy older adults …

Diabetes in pregnancy is not only associated with increased risk of pregnancy complications
and subsequent maternal metabolic disease, but also increases the risk of long-term …

Highly reproducible smoking-associated DNA methylation changes in whole blood have
been reported by many Epigenome-Wide-Association Studies (EWAS). These epigenetic …