Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …

Many plant virus genera encode a 'triple gene block'(TGB), a specialized evolutionarily
conserved gene module involved in the cell-to-cell and long-distance movement of viruses …

After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon
growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and …

Helicases use the energy derived from nucleoside triphosphate hydrolysis to unwind double
helices in essentially every metabolic pathway involving nucleic acids. Earlier crystal …

Helicase protein was first discovered in Escherichia coli in 1976 (1, 2). Since then RNA and
DNA helicases with diverse functions have been found in all organisms. Helicases couple …

Many helicases modulate recombination, an essential process that needs to be tightly
controlled. Mutations in some human disease helicases cause increased recombination …

Helicases are molecular motors that separate DNA strands for efficient replication of
genomes. We probed the kinetics of individual ring-shaped T7 helicase molecules as they …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

Translocation of helicase-like proteins on nucleic acids underlies key cellular functions.
However, it is still unclear how translocation can drive removal of DNA-bound proteins, and …

The SF1 DNA helicases are multi-domain proteins that can unwind duplex DNA in reactions
that are coupled to ATP binding and hydrolysis. Crystal structures of two such helicases …