It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

Cystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung
disease, characterized by recurrent and chronic bacterial infection and inflammation since …

During the last decades, tremendous chemical efforts have been dedicated to design
monovalent inhibitors of carbohydrate‐processing enzymes, with comparatively few rewards …

A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly
emerging area with exciting potential and scope. This review presents a description of the …

Glycosidases are ubiquitous enzymes involved in a diversity of key biological processes
such as energy uptake or cell wall degradation. The design of specific glycosidase inhibitors …

Glycosidases are extremely widespread enzymes responsible for the cleavage of glycosidic
bonds in glycoconjugates found in living organisms. Although it was well-known that the …

This review comprehensively covers the most recent achievements (from 2013) in the
successful integration of nanomaterials in the field of glycomics. The first part of the paper …

The multivalent effect in glycosidase inhibition is rapidly emerging as a hot topic of the
research. In the last five years, several iminosugar-based inhibitors showed remarkable …

Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide
range of biological activities exhibited by these glycomimetics associated with their excellent …

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based
glycopolypeptides evidenced remarkable multivalency properties when inhibiting α …