Evolved Cas9 proteins for gene editing

DR Liu, JH Hu - US Patent 12,043,852, 2024‏ - Google Patents
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …

Programmable CAS9-recombinase fusion proteins and uses thereof

DR Liu, B Chaikind, JL Bessen - US Patent 11,661,590, 2023‏ - Google Patents
2019-02-25 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Uses of adenosine base editors

DR Liu, NM Gaudelli, MS Packer, G Newby - US Patent 11,795,443, 2023‏ - Google Patents
2021-01-20 Assigned to BEAM THERAPEUTICS INC., PRESIDENT AND FELLOWS OF
HARVARD COLLEGE reassignment BEAM THERAPEUTICS INC. ASSIGNMENT OF …

Editing of CCR2 receptor gene to protect against HIV infection

JP Maianti, DR Liu - US Patent 11,820,969, 2023‏ - Google Patents
2022-08-24 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Base editors and uses thereof

DR Liu, LW Koblan, CG Wilson, JL Doman - US Patent 12,157,760, 2024‏ - Google Patents
2020-12-30 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Suppression of pain by gene editing

JP Maianti, DR Liu - US Patent 11,898,179, 2024‏ - Google Patents
2022-03-23 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Nuclease profiling system

DR Liu, V Pattanayak - US Patent 11,920,181, 2024‏ - Google Patents
2022-04-26 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

High efficiency base editors comprising Gam

DR Liu, KT Zhao, Y Kim - US Patent 11,932,884, 2024‏ - Google Patents
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …

Methods and compositions for prime editing nucleotide sequences

DR Liu, AV Anzalone - US Patent 11,795,452, 2023‏ - Google Patents
2022-09-14 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Incorporation of unnatural amino acids into proteins using base editing

JP Maianti, DR Liu, LW Koblan - US Patent 12,084,663, 2024‏ - Google Patents
2023-02-15 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …