The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates
the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here …

Streptococcus pneumoniae is a major human pathogen and rising resistance to β-lactam
antibiotics, such as penicillin, is a significant threat to global public health. Mutations …

In Staphylococcus aureus, resistance to β-lactamase stable β-lactam antibiotics is mediated
by the penicillinbinding protein 2a, encoded by mecA or by its homologues mecB or mecC …

Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages
underscores the need for new therapeutic strategies. Here we show that many S …

Antimicrobials can impact bacterial physiology and host immunity with negative treatment
outcomes. Extensive exposure to antifolate antibiotics promotes thymidine-dependent …

Acquisition of PBP2a (encoded by the mec gene) is the key resistance mechanism to β-
lactams in Staphylococcus aureus. The mec gene can be easily detected by PCR assays; …

Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of
invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections; however, mec …

ABSTRACT A major determinant of β-lactam resistance in methicillin-resistant
Staphylococcus aureus (MRSA) is the drug insensitive transpeptidase, PBP2a, encoded by …

Cyclic di-AMP (c-di-AMP) is an essential and ubiquitous second messenger among bacteria.
c-di-AMP regulates many cellular pathways through direct binding to several molecular …