Proteomics is the field of study that includes the analysis of proteins, from either a basic
science prospective or a clinical one. Proteins can be investigated for their abundance …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

An algorithm for the assignment of phosphorylation sites in peptides is described. The
program uses tandem mass spectrometry data in conjunction with the respective peptide …

The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …

Photodissociation mass spectrometry combines the ability to activate and fragment ions
using photons with the sensitive detection of the resulting product ions by mass …

Mass spectrometry (MS) has become a crucial technique for the analysis of protein
complexes. Native MS has traditionally examined protein subunit arrangements, while …

Post-translational modifications define the functional and structural plasticity of proteins in
archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein …

This unit outlines the steps required to prepare a sample for MS analysis following protein
separation or enrichment by gel electrophoresis, liquid chromatography, and affinity capture …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

How does the development of mass spectrometry (MS) for the study of protein complexes,
intact in the gas phase, contribute to the twin fields of genomics and proteomics? Foremost …