Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

The BCl-2 family has long been identified for its role in apoptosis. Following the initial
discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous …

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of
apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial …

Impaired apoptosis plays a central role in cancer development and limits the efficacy of
conventional cytotoxic therapies. Deepening understanding of how opposing factions of the …

Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway.
The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death …

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …

The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …