Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …

Novel immunotherapy approaches have provided durable remission in a significant number
of cancer patients with cancers previously considered rapidly lethal. Nonetheless, the high …

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

Background The epithelial-mesenchymal transition (EMT) enables dissociation of tumour
cells from the primary tumour mass, invasion through the extracellular matrix, intravasation …

Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized
to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no …