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DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
[BOK][B] RNA, the epicenter of genetic information
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes
R Li, M Gong, X Zhang, F Wang, Z Liu… - Genome …, 2023 - genome.cshlp.org
Structural variations (SVs) are a major contributor to genetic diversity and phenotypic
variations, but their prevalence and functions in domestic animals are largely unexplored …
variations, but their prevalence and functions in domestic animals are largely unexplored …
Platypus and echidna genomes reveal mammalian biology and evolution
Egg-laying mammals (monotremes) are the only extant mammalian outgroup to therians
(marsupial and eutherian animals) and provide key insights into mammalian evolution …
(marsupial and eutherian animals) and provide key insights into mammalian evolution …
Autonomous transposons tune their sequences to ensure somatic suppression
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
Causes and consequences of varying transposable element activity: An evolutionary perspective
Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes,
including humans. This evolutionary success of TEs is due to their replicative activity …
including humans. This evolutionary success of TEs is due to their replicative activity …
LINE-1 protein localization and functional dynamics during the cell cycle
LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …
[HTML][HTML] On the population dynamics of junk: a review on the population genomics of transposable elements
Y Bourgeois, S Boissinot - Genes, 2019 - mdpi.com
Transposable elements (TEs) play an important role in sha** genomic organization and
structure, and may cause dramatic changes in phenotypes. Despite the genetic load they …
structure, and may cause dramatic changes in phenotypes. Despite the genetic load they …
Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae)
Cetaceans are a clade of highly specialized aquatic mammals that include the largest
animals that have ever lived. The largest whales can have∼ 1,000× more cells than a …
animals that have ever lived. The largest whales can have∼ 1,000× more cells than a …
Genomic Analysis Revealed a Convergent Evolution of LINE-1 in Coat Color: A Case Study in Water Buffaloes (Bubalus bubalis)
D Liang, P Zhao, J Si, L Fang… - Molecular Biology …, 2021 - academic.oup.com
Visible pigmentation phenotypes can be used to explore the regulation of gene expression
and the evolution of coat color patterns in animals. Here, we performed whole-genome and …
and the evolution of coat color patterns in animals. Here, we performed whole-genome and …