DNA damage and repair in age-related inflammation

Y Zhao, M Simon, A Seluanov… - Nature Reviews …, 2023 - nature.com
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

[BOK][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes

R Li, M Gong, X Zhang, F Wang, Z Liu… - Genome …, 2023 - genome.cshlp.org
Structural variations (SVs) are a major contributor to genetic diversity and phenotypic
variations, but their prevalence and functions in domestic animals are largely unexplored …

Platypus and echidna genomes reveal mammalian biology and evolution

Y Zhou, L Shearwin-Whyatt, J Li, Z Song, T Hayakawa… - Nature, 2021 - nature.com
Egg-laying mammals (monotremes) are the only extant mammalian outgroup to therians
(marsupial and eutherian animals) and provide key insights into mammalian evolution …

Autonomous transposons tune their sequences to ensure somatic suppression

İA Ilık, P Glažar, K Tse, B Brändl, D Meierhofer… - Nature, 2024 - nature.com
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …

Causes and consequences of varying transposable element activity: An evolutionary perspective

AJ Betancourt, KHC Wei, Y Huang… - Annual Review of …, 2024 - annualreviews.org
Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes,
including humans. This evolutionary success of TEs is due to their replicative activity …

LINE-1 protein localization and functional dynamics during the cell cycle

P Mita, A Wudzinska, X Sun, J Andrade, S Nayak… - Elife, 2018 - elifesciences.org
LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …

[HTML][HTML] On the population dynamics of junk: a review on the population genomics of transposable elements

Y Bourgeois, S Boissinot - Genes, 2019 - mdpi.com
Transposable elements (TEs) play an important role in sha** genomic organization and
structure, and may cause dramatic changes in phenotypes. Despite the genetic load they …

Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae)

M Tollis, J Robbins, AE Webb… - Molecular biology …, 2019 - academic.oup.com
Cetaceans are a clade of highly specialized aquatic mammals that include the largest
animals that have ever lived. The largest whales can have∼ 1,000× more cells than a …

Genomic Analysis Revealed a Convergent Evolution of LINE-1 in Coat Color: A Case Study in Water Buffaloes (Bubalus bubalis)

D Liang, P Zhao, J Si, L Fang… - Molecular Biology …, 2021 - academic.oup.com
Visible pigmentation phenotypes can be used to explore the regulation of gene expression
and the evolution of coat color patterns in animals. Here, we performed whole-genome and …