Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics

M Sharifi, M Kamalabadi-Farahani, M Salehi… - Journal of …, 2024 - Springer
Several studies suggest that topographical patterns influence nerve cell fate. Efforts have
been made to improve nerve cell functionality through this approach, focusing on …

Beyond the limiting gap length: peripheral nerve regeneration through implantable nerve guidance conduits

ER Riva, M Özkan, E Contreras, S Pawar… - Biomaterials …, 2024 - pubs.rsc.org
Peripheral nerve damage results in the loss of sensorimotor and autonomic functions, which
is a significant burden to patients. Furthermore, nerve injuries greater than the limiting gap …

[HTML][HTML] Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications

BV Ineichen, E Furrer, SL Grüninger, WE Zürrer… - PLoS …, 2024 - journals.plos.org
There is an ongoing debate about the value of animal experiments to inform medical
practice, yet there are limited data on how well therapies developed in animal studies …

Current perspectives on peripheral nerve repair and management of the nerve gap

LA McMorrow, P Czarnecki… - Journal of Hand …, 2024 - journals.sagepub.com
From the first surgical repair of a nerve in the 6th century, progress in the field of peripheral
nerve surgery has marched on; at first slowly but today at great pace. Whether performing …

[PDF][PDF] Therapeutic strategies for nerve injuries: Current findings and future perspectives. Are textile technologies a potential solution

CV Vancea, A Grosu-Bularda, A Cretu… - Ind …, 2022 - revistaindustriatextila.ro
Peripheral nerve lesions represent debilitating conditions that determine sensitive, motor
and associated psychosocial losses, deeply and severely affecting the quality of life. Despite …

Nerve graft for erectile dysfunction after radical prostatectomy: animal study and clinical data—a narrative review

T Shu, D Ren, Y Cao, R Wang - International journal of impotence …, 2024 - nature.com
Introduced in the late 1990s, nerve grafting, particularly with sural and genitofemoral nerves,
aims to enhance erectile function recovery when neurovascular bundles cannot be …

Peripheral blood mononuclear cells regulate differentially expressed proteins in the proximal sciatic nerve of rats after transection anastomosis

Y Wu, X Liu, Y Han, L Li, M Jian, G Sun, J Nie - Neuroscience, 2022 - Elsevier
Peripheral nerve injury (PNI) is a common disease that causes the partial loss of sensory,
exercise, and autonomic nervous function. In clinical practice, accurate end-to-end …

[HTML][HTML] Muscle-in-vein conduits for the treatment of symptomatic Neuroma of sensory digital nerves

IA Ederer, J Kolbenschlag, A Daigeler… - Journal of Personalized …, 2022 - mdpi.com
Background: Considering the debilitating burden of neuroma resulting in a significant loss of
function and excruciating pain, the use of muscle-in-vein conduits (MVCs) for the …

[HTML][HTML] Fenugreek seed extract combined with acellular nerve allografts promotes peripheral nerve regeneration and neovascularization in sciatic nerve defects

Y Han, Z Liu, C Song - Regenerative Therapy, 2025 - Elsevier
Abstract Background Acellular nerve allografts (ANAs) have been confirmed to improve the
repair and reconstruction of long peripheral nerve defects. However, its efficacy is not …

[HTML][HTML] ESWT diminishes axonal regeneration following repair of the rat median nerve with muscle-in-vein conduits but not after autologous nerve grafting

JC Heinzel, V Oberhauser, C Keibl, B Schädl… - Biomedicines, 2022 - mdpi.com
Investigations reporting positive effects of extracorporeal shockwave therapy (ESWT) on
nerve regeneration are limited to the rat sciatic nerve model. The effects of ESWT on muscle …