Current approaches to the management of brain metastases

JH Suh, R Kotecha, ST Chao, MS Ahluwalia… - Nature reviews Clinical …, 2020 - nature.com
Brain metastases are a very common manifestation of cancer that have historically been
approached as a single disease entity given the uniform association with poor clinical …

Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions

AA Aizer, N Lamba, MS Ahluwalia, K Aldape… - Neuro …, 2022 - academic.oup.com
Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is
known about brain metastases than cancer-related entities of similar incidence. Advances in …

Survival in patients with brain metastases: summary report on the updated diagnosis-specific graded prognostic assessment and definition of the eligibility quotient

PW Sperduto, S Mesko, J Li, D Cagney… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for
clinical trials for fear that poor survival could mask the benefit of otherwise promising …

Management of brain metastases according to molecular subtypes

R Soffietti, M Ahluwalia, N Lin, R Rudà - Nature Reviews Neurology, 2020 - nature.com
The incidence of brain metastases has markedly increased in the past 20 years owing to
progress in the treatment of malignant solid tumours, earlier diagnosis by MRI and an …

Mechanisms and therapy for cancer metastasis to the brain

F Franchino, R Rudà, R Soffietti - Frontiers in oncology, 2018 - frontiersin.org
Advances in chemotherapy and targeted therapies have improved survival in cancer
patients with an increase of the incidence of newly diagnosed brain metastases (BMs) …

[HTML][HTML] State of the art in combination immuno/radiotherapy for brain metastases: systematic review and meta-analysis

M Najafi, A Jahanbakhshi, M Gomar, C Iotti… - Current …, 2022 - mdpi.com
Objectives: Common origins for brain metastases (BMs) are melanoma, lung, breast, and
renal cell cancers. BMs account for a large share of morbidity and mortality caused by these …

Current multidisciplinary management of brain metastases

MJ Moravan, PE Fecci, CK Anders, JM Clarke… - Cancer, 2020 - Wiley Online Library
Brain metastasis (BM), the most common adult brain tumor, develops in 20% to 40% of
patients with late‐stage cancer and traditionally are associated with a poor prognosis. The …

Initial SRS for patients with 5 to 15 brain metastases: results of a multi-institutional experience

RT Hughes, AH Masters, ER McTyre, MK Farris… - International Journal of …, 2019 - Elsevier
Purpose Several studies evaluating stereotactic radiosurgery (SRS) for patients with> 4
brain metastases (BM) demonstrated similar outcomes after treatment of 1, 2 to 4, and 5 to …

Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors

ÁF Álvarez-Prado, RR Maas, K Soukup, F Klemm… - Cell Reports …, 2023 - cell.com
Brain metastases (BrMs) are the most common form of brain tumors in adults and frequently
originate from lung and breast primary cancers. BrMs are associated with high mortality …

Melanoma brain metastasis presentation, treatment, and outcomes in the age of targeted and immunotherapies

ED Bander, M Yuan, JA Carnevale, AS Reiner… - Cancer, 2021 - Wiley Online Library
Background Historically, the prognosis for patients who have melanoma brain metastasis
(MBM) has been dismal. However, breakthroughs in targeted and immunotherapies have …