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Post-transcriptional regulation of anti-apoptotic BCL2 family members
Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …
Transcriptomic evidence for visual adaptation during the aquatic to terrestrial metamorphosis in leopard frogs
Background Differences in morphology, ecology, and behavior through ontogeny can result
in opposing selective pressures at different life stages. Most animals, however, transition …
in opposing selective pressures at different life stages. Most animals, however, transition …
Zeta-crystallin: a moonlighting player in cancer
Crystallins were firstly found as structural proteins of the eye lens. To this family belong
proteins, such as ζ-crystallin, expressed ubiquitously, and endowed with enzyme activity. ζ …
proteins, such as ζ-crystallin, expressed ubiquitously, and endowed with enzyme activity. ζ …
Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk
Acidosis arises in solid and lymphoid malignancies secondary to altered nutrient supply and
utilization. Tumor acidosis correlates with therapeutic resistance, although the mechanism …
utilization. Tumor acidosis correlates with therapeutic resistance, although the mechanism …
Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS …
L Cavone, R Felici, A Lapucci, D Buonvicino… - Brain, behavior, and …, 2015 - Elsevier
Fingolimod affords protection from MS by sequestering lymphocytes in secondary lymphoid
organs via down regulation of their sphingosine 1 phosphate receptor (S1P1) …
organs via down regulation of their sphingosine 1 phosphate receptor (S1P1) …
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels
Resistin is a polypeptide hormone that was reported to be associated with insulin resistance,
inflammation and risk of type 2 diabetes and cardiovascular disease. We conducted a …
inflammation and risk of type 2 diabetes and cardiovascular disease. We conducted a …
An analysis combining proteomics and transcriptomics revealed a regulation target of sea cucumber autolysis
T Yan, J Sun, J Zheng, J Yang - … and Physiology Part D: Genomics and …, 2024 - Elsevier
Sea cucumber is a valuable seafood product and autolysis is the main concern for the
aquaculture industry. This study employed proteomics and transcriptomics to investigate the …
aquaculture industry. This study employed proteomics and transcriptomics to investigate the …
Novel targets in a high-altitude pulmonary hypertension rat model based on RNA-seq and proteomics
X Xu, H Li, Q Wei, X Li, Y Shen, G Guo, Y Chen… - Frontiers in …, 2021 - frontiersin.org
High-altitude pulmonary hypertension (HAPH) is a complication arising from an inability to
acclimatize to high altitude and is associated with high morbidity and mortality. We aimed to …
acclimatize to high altitude and is associated with high morbidity and mortality. We aimed to …
Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers
T Weinschenk, M Andrea, J Fritsche… - US Patent App. 15 …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52630910&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52630910&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress
Master regulator protein p53, popularly known as the “guardian of genome” is the hub for
regulation of diverse cellular pathways. Depending on the cell type and severity of DNA …
regulation of diverse cellular pathways. Depending on the cell type and severity of DNA …