Post-transcriptional regulation of anti-apoptotic BCL2 family members

J Cui, WJ Placzek - International journal of molecular sciences, 2018 - mdpi.com
Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …

Transcriptomic evidence for visual adaptation during the aquatic to terrestrial metamorphosis in leopard frogs

RK Schott, RC Bell, ER Loew, KN Thomas, DJ Gower… - BMC biology, 2022 - Springer
Background Differences in morphology, ecology, and behavior through ontogeny can result
in opposing selective pressures at different life stages. Most animals, however, transition …

Zeta-crystallin: a moonlighting player in cancer

M Lulli, D Nencioni, L Papucci, N Schiavone - Cellular and Molecular Life …, 2020 - Springer
Crystallins were firstly found as structural proteins of the eye lens. To this family belong
proteins, such as ζ-crystallin, expressed ubiquitously, and endowed with enzyme activity. ζ …

Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk

C Ryder, K McColl, F Zhong, CW Distelhorst - Journal of Biological …, 2012 - jbc.org
Acidosis arises in solid and lymphoid malignancies secondary to altered nutrient supply and
utilization. Tumor acidosis correlates with therapeutic resistance, although the mechanism …

Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS …

L Cavone, R Felici, A Lapucci, D Buonvicino… - Brain, behavior, and …, 2015 - Elsevier
Fingolimod affords protection from MS by sequestering lymphocytes in secondary lymphoid
organs via down regulation of their sphingosine 1 phosphate receptor (S1P1) …

Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels

Q Qi, C Menzaghi, S Smith, L Liang… - Human molecular …, 2012 - academic.oup.com
Resistin is a polypeptide hormone that was reported to be associated with insulin resistance,
inflammation and risk of type 2 diabetes and cardiovascular disease. We conducted a …

An analysis combining proteomics and transcriptomics revealed a regulation target of sea cucumber autolysis

T Yan, J Sun, J Zheng, J Yang - … and Physiology Part D: Genomics and …, 2024 - Elsevier
Sea cucumber is a valuable seafood product and autolysis is the main concern for the
aquaculture industry. This study employed proteomics and transcriptomics to investigate the …

Novel targets in a high-altitude pulmonary hypertension rat model based on RNA-seq and proteomics

X Xu, H Li, Q Wei, X Li, Y Shen, G Guo, Y Chen… - Frontiers in …, 2021 - frontiersin.org
High-altitude pulmonary hypertension (HAPH) is a complication arising from an inability to
acclimatize to high altitude and is associated with high morbidity and mortality. We aimed to …

Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers

T Weinschenk, M Andrea, J Fritsche… - US Patent App. 15 …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52630910&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress

N Bansal, R Kadamb, S Mittal, L Vig, R Sharma… - PLoS …, 2011 - journals.plos.org
Master regulator protein p53, popularly known as the “guardian of genome” is the hub for
regulation of diverse cellular pathways. Depending on the cell type and severity of DNA …