Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further …

Psychiatric disorders affect 970 million people worldwide, representing a significant source
of disability. Although the underlying neurobiological traits for these disorders are not fully …

Western dietary patterns have been unfavorably linked with mental health. However, the
long-term effects of habitual fried food consumption on anxiety and depression and …

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional
inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional …

Abstract Changes of sphingolipid metabolism were suggested to contribute to the patho-
etiology of major depression (MD) and bipolar disorder (BD). In a pilot study we assessed if …

The central nervous system has the second highest concentration of lipids after adipose
tissue. Alterations in neural membrane phospho-and sphingolipid composition can influence …

Brain is a central and pivotal organ of human body containing the highest lipids content next
to adipose tissue. It works as a monitor for the whole body and needs an adequate supply of …

Major depressive disorder (MDD), also called depression, is a serious disease that impairs
the quality of life of patients and has a high incidence, affecting approximately 3.8% of the …

Lipid rafts, the sphingolipid and cholesterol-enriched membrane microdomains, are able to
form different membrane macrodomains or platforms upon stimulations, including redox …

Retinal photoreceptors are highly specialized and performing neurons. Their cellular
architecture is exquisitely designed to host a high concentration of molecules involved in …