Chromatin accessibility provides a window into the genetic etiology of human brain disease
Neuropsychiatric and neurodegenerative diseases have a significant genetic component.
Risk variants often affect the noncoding genome, altering cis-regulatory elements (CREs) …
Risk variants often affect the noncoding genome, altering cis-regulatory elements (CREs) …
Contrasting genetic predisposition and diagnosis in psychiatric disorders: a multi-omic single-nucleus analysis of the human orbitofrontal cortex
Psychiatric disorders like schizophrenia, bipolar disorder, and major depressive disorder
exhibit significant genetic and clinical overlap. However, their molecular architecture …
exhibit significant genetic and clinical overlap. However, their molecular architecture …
ECLARE: multi-teacher contrastive learning via ensemble distillation for diagonal integration of single-cell multi-omic data
Integrating multimodal single-cell data, such as scRNA-seq and scATAC-seq, is key for
decoding gene regulatory networks but remains challenging due to issues like feature …
decoding gene regulatory networks but remains challenging due to issues like feature …