Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Don't eat me/eat me signals as a novel strategy in cancer immunotherapy

A Khalaji, FB Yancheshmeh, F Farham, A Khorram… - Heliyon, 2023 - cell.com
Cancer stands as one of the prominent global causes of death, with its incidence burden
continuously increasing, leading to a substantial rise in mortality rates. Cancer treatment has …

[HTML][HTML] Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

L Braga, H Ali, I Secco, E Chiavacci, G Neves… - Nature, 2021 - nature.com
COVID-19 is a disease with unique characteristics that include lung thrombosis, frequent
diarrhoea, abnormal activation of the inflammatory response and rapid deterioration of lung …

Structural and functional consequences of reversible lipid asymmetry in living membranes

M Doktorova, JL Symons, I Levental - Nature chemical biology, 2020 - nature.com
Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM)
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …

[HTML][HTML] Sperm lipid markers of male fertility in mammals

S Shan, F Xu, M Hirschfeld, B Brenig - International Journal of Molecular …, 2021 - mdpi.com
Sperm plasma membrane lipids are essential for the function and integrity of mammalian
spermatozoa. Various lipid types are involved in each key step within the fertilization …

Putting the brakes on phagocytosis:“don't‐eat‐me” signaling in physiology and disease

SM Kelley, KS Ravichandran - EMBO reports, 2021 - embopress.org
Timely removal of dying or pathogenic cells by phagocytes is essential to maintaining host
homeostasis. Phagocytes execute the clearance process with high fidelity while sparing …

Flagging fusion: Phosphatidylserine signaling in cell–cell fusion

JM Whitlock, LV Chernomordik - Journal of Biological Chemistry, 2021 - jbc.org
Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …

Phosphatidylserine exposure in living cells

HW Shin, H Takatsu - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
P4-ATPases, a subfamily of P-type ATPases, translocate cell membrane phospholipids from
the exoplasmic/luminal leaflet to the cytoplasmic leaflet to generate and maintain membrane …

The fertilization enigma: how sperm and egg fuse

VE Deneke, A Pauli - Annual review of cell and developmental …, 2021 - annualreviews.org
Fertilization is a multistep process that culminates in the fusion of sperm and egg, thus
marking the beginning of a new organism in sexually reproducing species. Despite its …

Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?

L Atkinson, F Martin, RG Sturmey - Human Reproduction, 2021 - academic.oup.com
The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related
declines in fertility or in pathological conditions such as premature ovarian failure. The …