Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that
are poorly understood. Notably, instead of through the induction of angiogenesis, tumor …

ABSTRACT Bone morphogenetic protein 2 (BMP-2) has been known for decades as a
strong osteoinductive factor and for clinical applications is combined solely with collagen as …

The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted
therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we …

Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have
been implicated in different aspects of cancer cell survival and metastasis. Here, we …

Endocytosis plays a crucial role in receptor signalling. VEGFR2 (also known as KDR) and its
ligand VEGFA are fundamental in neovascularisation. However, our understanding of the …

Glucagon-like peptide-1 receptor (GLP-1R) plays a major role in promoting glucose-
stimulated insulin secretion in pancreatic β-cells. In the present study, we synthesized a …

BPC 157, a pentadecapeptide with extensive healing effects, has recently been suggested
to contribute to angiogenesis. However, the underlying mechanism is not yet clear. The …

Transcription factor TFEB is thought to control cellular functions—including in the vascular
bed—primarily via regulation of lysosomal biogenesis and autophagic flux. Here, we report …

Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of
VEGFR2. However, how these cell behaviors are regulated individually is still unknown …