Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Centrosome amplification is a common feature of human tumors, but whether this is a cause
or a consequence of cancer remains unclear. Here, we test the consequence of centrosome …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Precise regulation of centrosome number is critical for accurate chromosome segregation
and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers …

Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to
represent premature aging phenotypes. At times, they cluster in families, but the genetic …

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or
senescence is often triggered after mitotic exit. To characterize this process, we conducted …

In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the
airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to …

Centrioles are microtubule-based core components of centrosomes and cilia. They are
duplicated exactly once during S-phase progression. Central to formation of each new …