Terpenoids constitute one of the largest and most chemically diverse classes of primary and
secondary metabolites in nature with an exceptional breadth of functional roles in plants …

Isoprenoids constitute one of the most diverse classes of natural products. As a compound
class, they are essential to basic metabolic processes including cell-wall biosynthesis, post …

When compared to other organisms, plants are atypical with respect to isoprenoid
biosynthesis: they utilize two distinct and separately compartmentalized pathways to build …

Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids
are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl …

Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new
opportunities for drug development. The apicoplast–although no longer photosynthetic–is …

While most T cells use a CD3-associated α/β T cell receptor as antigen recognition structure,
a second population of T cells expresses the alternative y/8 T cell receptor. γ/δ T cells are a …

Human Vγ9/Vδ2 T cells play a crucial role in the immune response to microbial pathogens,
yet their unconventional reactivity towards non-peptide antigens has been enigmatic until …

The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the biosynthesis of
isopentenyl diphosphate (IDP) and dimethylallyl diphosphate (DMADP), the precursors for …

Carotenoids are isoprenoid pigments that function as photoprotectors, precursors of the
hormone abscisic acid (ABA), colorants and nutraceuticals. A major problem for the …

Apart from their activity in combating infections, neutrophils play an important role in
regulating the tumor microenvironment. Neutrophils can directly kill (antibody-coated) …