Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

Many clinically useful antibiotics exert their antimicrobial effects by blocking protein
synthesis on the bacterial ribosome. The structure of the ribosome has recently been …

Host protection from infection relies on the recognition of pathogens by innate pattern-
recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan …

A key parameter influencing the rate and trajectory of the evolution of antibiotic resistance is
the fitness cost of resistance. Recent studies have demonstrated that antibiotic resistance …

The ribosomal peptidyl transferase center (PTC) resides in the large ribosomal subunit and
catalyzes the two principal chemical reactions of protein synthesis: peptide bond formation …

Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular
structures and metabolic pathways. The finding that patients with mutations in mitochondrial …

Several classes of clinically important antibiotics target the bacterial ribosome, where they
interfere with microbial protein synthesis. Structural studies of the interaction of antibiotics …

Macrolide antibiotics bind in the nascent peptide exit tunnel of the ribosome and inhibit
protein synthesis. The majority of information on the principles of binding and action of these …

The ribosome is one of the main antibiotic targets in the cell. Recent years brought important
insights into the mode of interaction of antibiotics with the ribosome and mechanisms of …

Objectives Antibiotic therapy of pulmonary Mycobacterium abscessus infection is based on a
combination treatment including clarithromycin. Recent data demonstrated that M …